Imprinting and looping: epigenetic marks control interactions between regulatory elements.

Yuzuru Kato; Hiroyuki Sasaki

doi:10.1002/bies.20171

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Imprinting and looping: epigenetic marks control interactions between regulatory elements.

Yuzuru Kato·Hiroyuki Sasaki

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Abstract

Gene regulation involves various cis-regulatory elements that can act at a distance. They may physically interact each other or with their target genes to exert their effects. Such interactions are beginning to be uncovered in the imprinted Igf2/H19 domain.(1) The differentially methylated regions (DMRs), containing insulators, silencers and activators, were shown to have physical contacts between them. The interactions were changeable depending on their epigenetic state, presumably enabling Igf2 to move between an active and a silent chromatin domain. The study gives us a novel view on how regulatory elements influence gene expression and how epigenetic modifications modulate their long-range effects.

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Alleles Animals Cell Nucleus Chromatin Enhancer Elements, Genetic Genomic Imprinting Humans Methylation Models, Biological Models, Genetic Multigene Family Protein Binding Protein Structure, Tertiary Journal Article Review

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Yuzuru Kato, Hiroyuki Sasaki. 2005. Imprinting and looping: epigenetic marks control interactions between regulatory elements.. https://doi.org/10.1002/bies.20171

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