Development and validation of computational models of cellular interaction.

R H Smallwood; W M L Holcombe; D C Walker

doi:10.1007/s10735-004-2660-1

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Development and validation of computational models of cellular interaction.

R H Smallwood·W M L Holcombe·D C Walker

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Abstract

In this paper we take the view that computational models of biological systems should satisfy two conditions - they should be able to predict function at a systems biology level, and robust techniques of validation against biological models must be available. A modelling paradigm for developing a predictive computational model of cellular interaction is described, and methods of providing robust validation against biological models are explored, followed by a consideration of software issues.

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Animals Cell Physiological Phenomena Computer Simulation Epithelium Models, Biological Software Journal Article Validation Study

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R H Smallwood, W M L Holcombe, D C Walker. 2004. Development and validation of computational models of cellular interaction.. https://doi.org/10.1007/s10735-004-2660-1

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