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PubMed · 15621727

Human interferons alpha, beta and omega.

Joseph Bekisz·Hana Schmeisser·Jessica Hernandez·Neil D Goldman·Kathryn C Zoon
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Abstract

Type I interferons (IFNs), IFN-alpha, IFN-beta, IFN-omega, IFN-delta and IFN-tau are a family of structurally related, species-specific proteins found only in vertebrates. They exhibit a variety of biological functions, including antiviral, antiproliferative, immunomodulatory and developmental activities. Human Type I IFNs interact with the human IFN alpha receptor (IFNAR), which is composed of two identified subunits (IFNAR-1 and IFNAR-2). The interaction of IFN-alpha/beta with its receptor components results in the activation of a number of signaling pathways. The regulation of specific genes and proteins contributes to the numerous biological functions of Type I IFNs.

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Amino Acid SequenceAnimalsHumansInterferon Type IInterferon-alphaInterferon-betaModels, BiologicalModels, MolecularMolecular Sequence DataPeptidesProtein Structure, SecondarySequence Homology, Amino AcidSignal TransductionStructure-Activity RelationshipJournal ArticleReview

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Joseph Bekisz, Hana Schmeisser, Jessica Hernandez, Neil D Goldman, Kathryn C Zoon. 2004. Human interferons alpha, beta and omega.. https://doi.org/10.1080/08977190400000833

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