PubMed · 15626043
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
Emphysema.. https://pubmed.ncbi.nlm.nih.gov/15626043/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Observational studies suggest an association between glioblastoma (GBM) and cardiovascular diseases (CVDs), but a causal relationship remains unestablished. This study aimed to investigate the causal link between multiple CVDs and GBM risk. The inverse variance weighted method indicated that all 18 CVDs had significant causal associations with GBM (P < .05). Genetically predicted CVDs were uniformly associated with a lower risk of GBM (odds ratio < 1), identifying them as potential protective factors. Sensitivity analyses confirmed the absence of significant heterogeneity or horizontal pleiotropy, and the MR-Steiger test validated the correct causal direction. This Mendelian randomization (MR) study provides evidence that a range of CVDs are causally associated with a decreased risk of developing GBM. These findings suggest shared biological pathways and offer new insights for understanding GBM etiology. We conducted a 2-sample MR analysis using publicly available genome-wide association study data. GBM was the outcome, and 18 cardiovascular-related traits (including coronary artery disease, myocardial infarction, and venous thromboembolism) were exposures. Instrumental variables were single-nucleotide polymorphisms significantly associated with exposures (P < 5 × 10-8). The primary analysis used the inverse variance weighted method, supplemented with MR-Egger, weighted median, and weighted mode methods. Sensitivity analyses, including Cochran Q test, MR-Egger intercept test, leave-one-out analysis, and MR-Steiger directionality test, were performed to ensure robustness.
Explore the source record for details and available documents.
Headache, fatigue, and vertigo are collectively the commonest symptoms encountered in clinical medicine, yet in many cases their true aetiopathogenesis is unknown or unclear. It is postulated that an important reason why little significant progress is being made towards discovering the true aetiology of these symptoms is because physicians, almost universally, are failing to examine a large part of the head for common, readily observable intraosseous pathology which could conceivably cause these symptoms. The region not examined comprises the mandible, maxillae, and their appendages, and the intraosseous pathology not examined for includes impacted teeth, devitalized teeth, and residual infection, amongst others. The non-examination for pathology which could cause these symptoms has thus created a major blind spot in clinical medicine. It is conservatively estimated that more than 50 million people on the American and European continents may thereby be denied a proper clinical examination for the aetiology of these symptoms. Readily testable data, indicating the extent to which the medical profession as a whole has overlooked this pathology, is provided.