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Trazodone influence on rat sera beta-endorphins level.

Radivoj Jadrić·Irfan Zulić·Sabaheta Hasić·Emina Kiseljaković·Belma Zecević·Jovan Radovanović·Emina Ićindić-Nakas·Mira Winterhalter-Jadrić
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Abstract

Some 25 years ago it was found that parts of CNS could produce strong analgesic response on little morphine quantities. Later studies proved the existence for dozen of morphine-like substances, called opioids, which are normally produced in the brain. The most important are endorphins, met- and leu-encephalin and dinorphin produced both in hypothalamus and pituitary gland. The aim of our study was to found whether and how strong produce of beta-endorphins is to be expected when psychotropic drugs are used. Trazodon as antidepressant was used, and RIA technique for quantification of sera beta-endorphins. The results showed significant difference in rat sera beta-endorphins between certain days of drug application. These studies showed that beta-endorphins could be of great importance, used as markers for evaluation of patient treatment and eventual abuse of psychotropic drugs.

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Radivoj Jadrić, Irfan Zulić, Sabaheta Hasić, Emina Kiseljaković, Belma Zecević, Jovan Radovanović, Emina Ićindić-Nakas, Mira Winterhalter-Jadrić. 2004. Trazodone influence on rat sera beta-endorphins level.. https://doi.org/10.17305/bjbms.2004.3411

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