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HAP1 and intracellular trafficking.

Xiao-Jiang Li·Shi-Hua Li
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Abstract

Huntington's disease is caused by a polyglutamine expansion in the protein huntingtin. Several studies suggest that huntingtin and its associated protein HAP1 participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport. A study now provides new evidence that HAP1 is also involved in the endocytosis of membrane receptors. These studies offer insight into the normal function of HAP1 and its involvement in Huntington's disease.

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AnimalsHumansHuntington DiseaseIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsPeptidesProtein TransportJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Xiao-Jiang Li, Shi-Hua Li. 2005. HAP1 and intracellular trafficking.. https://doi.org/10.1016/j.tips.2004.11.001

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