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Developments in glucocorticoid therapy.

Johannes W J Bijlsma·Kenneth G Saag·Frank Buttgereit·José A P da Silva
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Abstract

Recent evidence for a disease-modifying potential of low-dose glucocorticoids (GCs) in the treatment of rheumatoid arthritis has renewed the debate on the risk benefit ratio with this therapy. Two recent developments are described that might have a positive influence on these risk benefit ratios. One is the improvement in new GC compounds--designer GCs, alterations in bioactivity, and alterations in formulations. The other is a better understanding and management of the toxicity of GCs.

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AnimalsChemistry, PharmaceuticalDesigner DrugsGlucocorticoidsHumansReceptors, GlucocorticoidRheumatic DiseasesJournal ArticleReview

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Johannes W J Bijlsma, Kenneth G Saag, Frank Buttgereit, José A P da Silva. 2005. Developments in glucocorticoid therapy.. https://doi.org/10.1016/j.rdc.2004.10.003

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