Conceptualizing "suicidal genetically engineered microorganisms" for bioremediation applications.

Gunjan Pandey; Debarati Paul; Rakesh K Jain

doi:10.1016/j.bbrc.2004.12.080

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Conceptualizing "suicidal genetically engineered microorganisms" for bioremediation applications.

Gunjan Pandey·Debarati Paul·Rakesh K Jain

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Abstract

Use of genetically modified microorganisms (GEMs) for pollution abatement has been limited because of risks associated with their release in the environment. Recent developments in the area of recombinant DNA technologies have paved the way for conceptualizing "suicidal genetically engineered microorganisms" (S-GEMS) to minimize such anticipated hazards and to achieve efficient and safer bioremediation of contaminated sites. Our strategy of designing a novel S-GEM is based on the knowledge of killer-anti-killer gene(s) that would be susceptible to programmed cell death after detoxification of any given contaminated site(s).

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Bacteria Bacterial Toxins Biodegradation, Environmental DNA, Recombinant Environmental Monitoring Gene Transfer Techniques Genetic Engineering Killer Cells, Natural Microbiological Techniques Plasmids Risk Assessment Journal Article Research Support, Non-U.S. Gov't

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Gunjan Pandey, Debarati Paul, Rakesh K Jain. 2005-02-18. Conceptualizing "suicidal genetically engineered microorganisms" for bioremediation applications.. https://doi.org/10.1016/j.bbrc.2004.12.080

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