Does the AD7c-NTP locus encode a protein?

Jan Ole Kriegs; Jürgen Schmitz; Wojciech Makalowski; Jürgen Brosius

doi:10.1016/j.bbaexp.2004.12.002

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Does the AD7c-NTP locus encode a protein?

Jan Ole Kriegs·Jürgen Schmitz·Wojciech Makalowski·Jürgen Brosius

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Abstract

AD7c-NTP, the only known protein entirely encoded by tandem and nested cassettes of Alu repetitive elements, is reportedly over-expressed in brains of Alzheimer's disease patients [de la Monte et al., J. Clin. Invest. 15 (1997)]. Based on these findings a commercial diagnostic assay ("7c Gold"/"AlzheimAlert" ) has been developed. We analyzed the published cDNA sequence and compared it to corresponding EST clones as well as the genomic sequences of human and chimpanzee. We come to the conclusion that the existence of the gene and in particular the predicted protein is inconsistent with EST and genomic data. Previously published data need to be reassessed.

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Alu Elements Alzheimer Disease Animals Base Sequence Brain DNA, Complementary Humans Molecular Sequence Data Nerve Tissue Proteins Pan troglodytes Sequence Alignment Journal Article

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Jan Ole Kriegs, Jürgen Schmitz, Wojciech Makalowski, Jürgen Brosius. 2004-12-31. Does the AD7c-NTP locus encode a protein?. https://doi.org/10.1016/j.bbaexp.2004.12.002

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