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Ceramide: a new lipid "second messenger"?

A H Merrill
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Abstract

1-Alpha, 25-dihydroxyvitamin D3, tumor necrosis factor alpha, and gamma-interferon induce sphingomyelin turnover to ceramide in HL-60 cells. The time frame of the turnover is consistent with ceramide formation being a mediator of growth and differentiation; furthermore, differentiation can be induced by addition of exogenous ceramides alone. Hence, the action of the biologically active form of vitamin D and other nutritionally relevant factors may be mediated by lipid second messenger pathways involving sphingolipids.

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AnimalsCell DifferentiationCeramidesHumansSecond Messenger SystemsJournal ArticleReview

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BibTeXRIS

A H Merrill. 1992. Ceramide: a new lipid "second messenger"?. https://doi.org/10.1111/j.1753-4887.1992.tb01273.x

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