Assembly and function of RNA silencing complexes.

Erik J Sontheimer

doi:10.1038/nrm1568

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Assembly and function of RNA silencing complexes.

Erik J Sontheimer

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Abstract

In the RNA-interference pathway, double-stranded RNA induces sequence-specific mRNA degradation through the action of the RNA-induced silencing complex (RISC). Recent work has provided our first glimpses of the RISC-assembly pathway and uncovered the biochemical roles of critical RISC components. These advances have taken our mechanistic understanding of RNA interference to a new level and promise to improve our ability to exploit this biological process for use in experimental biology and medicine.

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Animals Binding Sites Chromatin Drosophila Humans Models, Biological Models, Chemical Models, Molecular Protein Structure, Tertiary RNA RNA Interference RNA, Messenger RNA, Small Interfering Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Erik J Sontheimer. 2005. Assembly and function of RNA silencing complexes.. https://doi.org/10.1038/nrm1568

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