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Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection.

Hiroshi Kimura·Yo Hoshino·Shinya Hara·Naomi Sugaya·Jun-Ichi Kawada·Yukiko Shibata·Seiji Kojima·Tetsuro Nagasaka·Kiyotaka Kuzushima·Tsuneo Morishima
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Abstract

Infections of T cells and natural killer (NK) cells play a central role in the pathogenesis of chronic active Epstein-Barr virus (CAEBV) infection. To characterize the virologic and cytokine profiles of T cell-type and NK cell-type infection, 39 patients with CAEBV infection were analyzed. Patients with T cell-type infection had higher titers of immunoglobulin G against early and late EBV antigens, suggesting lytic cycle infection. However, the pattern of EBV gene expression was latency type II; BZLF1, which is a hallmark of lytic cycle infection, could not be detected in any patients, regardless of infection type. Patients with CAEBV infection had high concentrations of proinflammatory, T helper cell type 1, and anti-inflammatory cytokines. The cytokine profile in patients with NK cell-type infection was similar to that in patients with T cell-type infection, but the concentration of IL-13 was high in patients with NK cell-type infection. These findings should help to clarify the pathogenesis of CAEBV infection and facilitate the development of more-effective treatments.

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AdolescentAdultAntibodies, ViralAntigens, ViralChildChild, PreschoolCytokinesDNA-Binding ProteinsEpstein-Barr Virus InfectionsFemaleHerpesvirus 4, HumanHumansImmunoglobulin GInterleukin-13Killer Cells, NaturalLymphocyte SubsetsMaleT-LymphocytesTrans-ActivatorsViral ProteinsJournal ArticleResearch Support, Non-U.S. Gov't

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Hiroshi Kimura, Yo Hoshino, Shinya Hara, Naomi Sugaya, Jun-Ichi Kawada, Yukiko Shibata, Seiji Kojima, Tetsuro Nagasaka, Kiyotaka Kuzushima, Tsuneo Morishima. 2005-01-06. Differences between T cell-type and natural killer cell-type chronic active Epstein-Barr virus infection.. https://doi.org/10.1086/427239

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