[Proteasome and proteolysis].

David Papapostolou; Michèle Reboud-Ravaux

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PubMed · 15662944

[Proteasome and proteolysis].

David Papapostolou·Michèle Reboud-Ravaux

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Abstract

The maintenance of cellular homeostasis and the ability of cells to respond to their environment depend on the degradation of bulk proteins and orderly degradation of key regulatory proteins and their inhibitors. The 26S proteasome plays an essential role in these degradations. It is involved in the activation and inactivation of many cellular processes such as cell cycle progression, apoptosis and regulation of gene expression. It presents unique structural and functional properties. It degrades proteins by an unusual mechanism. Several series of proteasome inhibitors have been developed, useful to elucidate the biological roles of this multicatalytic enzyme. Velcade (bortezomid) was the first proteasome inhibitor to undergo, in may 2003, clinical trials in cancer patients.

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Aging Animals Humans Hydrolysis Models, Biological Models, Molecular Oxidation-Reduction Protease Inhibitors Proteasome Endopeptidase Complex Protein Conformation Protein Processing, Post-Translational Protein Subunits Proteins Structure-Activity Relationship Ubiquitin English Abstract Journal Article Review

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David Papapostolou, Michèle Reboud-Ravaux. 2004. [Proteasome and proteolysis].. https://pubmed.ncbi.nlm.nih.gov/15662944/

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