Energy landscapes and solved protein-folding problems.

Peter G Wolynes

doi:10.1098/rsta.2004.1502

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Energy landscapes and solved protein-folding problems.

Peter G Wolynes

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Abstract

Energy-landscape theory has led to much progress in protein folding kinetics, protein structure prediction and protein design. Funnel landscapes describe protein folding and binding and explain how protein topology determines kinetics. Landscape-optimized energy functions based on bioinformatic input have been used to correctly predict low-resolution protein structures and also to design novel proteins automatically.

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Computer Simulation Energy Transfer Models, Chemical Models, Molecular Multiprotein Complexes Phase Transition Protein Conformation Protein Folding Proteins Temperature Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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Peter G Wolynes. 2005-02-15. Energy landscapes and solved protein-folding problems.. https://doi.org/10.1098/rsta.2004.1502

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