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[NiFe]-Hydrogenase maturation endopeptidase: structure and function.

E Theodoratou·R Huber·A Böck
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Abstract

Hydrogenase maturation endopeptidases catalyse the terminal step in the maturation of the large subunit of [NiFe]-hydrogenases. They remove a C-terminal extension from the precursor of the subunit, triggering a conformational switch that results in the bridging of the Fe and Ni atoms of the metal centre via the thiolate of a cysteine residue and in closure of the centre. This review summarizes what is known about the structure of the protein, its substrate specificity and its possible reaction mechanism.

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HydrogenaseStructure-Activity RelationshipSubstrate SpecificityJournal Article

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E Theodoratou, R Huber, A Böck. 2005. [NiFe]-Hydrogenase maturation endopeptidase: structure and function.. https://doi.org/10.1042/bst0330108

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