The mammalian Mediator complex.

Joan Weliky Conaway; Laurence Florens; Shigeo Sato; Chieri Tomomori-Sato; Tari J Parmely; Tingting Yao; Selene K Swanson; Charles A S Banks; Michael P Washburn; Ronald C Conaway

doi:10.1016/j.febslet.2004.11.031

PubMed · 15680972

The mammalian Mediator complex.

Joan Weliky Conaway·Laurence Florens·Shigeo Sato·Chieri Tomomori-Sato·Tari J Parmely·Tingting Yao·Selene K Swanson·Charles A S Banks·Michael P Washburn·Ronald C Conaway

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Abstract

The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complex.

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Animals Mammals Multiprotein Complexes Protein Subunits Proteomics Trans-Activators Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Joan Weliky Conaway, Laurence Florens, Shigeo Sato, Chieri Tomomori-Sato, Tari J Parmely, Tingting Yao, Selene K Swanson, Charles A S Banks, Michael P Washburn, Ronald C Conaway. 2005-02-07. The mammalian Mediator complex.. https://doi.org/10.1016/j.febslet.2004.11.031

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