ADAMs: key components in EGFR signalling and development.

Carl P Blobel

doi:10.1038/nrm1548

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ADAMs: key components in EGFR signalling and development.

Carl P Blobel

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Abstract

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.

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Amino Acid Sequence Animals Dimerization ErbB Receptors Heart Humans Metalloendopeptidases Molecular Sequence Data Neovascularization, Physiologic Signal Transduction Journal Article Review

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Carl P Blobel. 2005. ADAMs: key components in EGFR signalling and development.. https://doi.org/10.1038/nrm1548

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