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PubMed · 15688074

Multicomponent therapeutics for networked systems.

Curtis T Keith·Alexis A Borisy·Brent R Stockwell
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Abstract

Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.

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Clinical Trials as TopicDrug DesignDrug SynergismDrug Therapy, CombinationHumansTerminology as TopicJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Curtis T Keith, Alexis A Borisy, Brent R Stockwell. 2005. Multicomponent therapeutics for networked systems.. https://doi.org/10.1038/nrd1609

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