Target selection issues in drug discovery and development.

E A Sausville

doi:10.1179/joc.2004.16.supplement-1.16

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Target selection issues in drug discovery and development.

E A Sausville

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Abstract

Targets for cancer treatments have been proposed which address oncogenes mutated in tumors (pathogenic targets). Yet additional opportunities may come from molecules expressed in the tissue of origin (ontogenic); allow drug handling (pharmacological) or address the tumor microenvironment. The key is to define an assay that defines a therapeutic index which can be achieved in modulated target function.

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Animals Antineoplastic Agents Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Disease Models, Animal Drug Delivery Systems Drug Design Drug Screening Assays, Antitumor Female Forecasting Gene Targeting Genome, Human Humans Male Neoplasms Sensitivity and Specificity United States Journal Article Review

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E A Sausville. 2004. Target selection issues in drug discovery and development.. https://doi.org/10.1179/joc.2004.16.supplement-1.16

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