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Separating functional and structural damage in persistent vegetative state using combined voxel-based analysis of 3-D MRI and FDG-PET.

Freimut D Juengling·Jan Kassubek·Hans-Jürgen Huppertz·Thomas Krause·Thomas Els
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Abstract

Functional and structural damage in postanoxic persistent vegetative state (PVS) was analysed using 18fluorodeoxyglucose PET (FDG-PET) coregistered to 3-D MRI in combination with morphometric 3-D MRI analysis (voxel-based morphometry, VBM). In five patients in late stages of non-traumatic PVS, combined analysis using statistical parametric mapping (SPM2) was performed to compare metabolic impairment and structural loss. FDG-PET showed widespread hypometabolism at p<0.001 (corrected) in the parietal, parietooccipital and frontotemporal cortices, cingulum, frontal medial and precentral gyrus, and within the bilateral thalamus. VBM revealed multilocal structural loss at p<0.001 (corrected) in the inferior parietal and superior/medial frontal cortices, insula and operculum, superior and medial temporal lobes, cingulum and fusiform gyrus, caudate, midbrain, dorsal pons, and the cerebellum, but to a lesser extent in the thalamus. The selective vulnerability of the brain in a sample of PVS patients could be mapped in vivo, indicating that a complex structural and functional lesion pattern of the cerebral networks seems to be associated with this condition.

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AdultAtrophyBrainCerebrovascular CirculationEnergy MetabolismFemaleFluorodeoxyglucose F18Functional LateralityHumansHypoxia-Ischemia, BrainImage Processing, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedNerve NetPersistent Vegetative StatePositron-Emission TomographyJournal Article

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Freimut D Juengling, Jan Kassubek, Hans-Jürgen Huppertz, Thomas Krause, Thomas Els. 2005-01-06. Separating functional and structural damage in persistent vegetative state using combined voxel-based analysis of 3-D MRI and FDG-PET.. https://doi.org/10.1016/j.jns.2004.11.052

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