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PubMed · 15698031

Cooperativity between cell contractility and adhesion.

Igor L Novak·Boris M Slepchenko·Alex Mogilner·Leslie M Loew
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Abstract

In living cells, the cytoskeleton connects to the extracellular environment through focal adhesions, multimolecular structures that can sense applied force. A model is presented that for the first time explains why the focal adhesions tend to high-curvature regions at the cell periphery. It is based on experimental evidence for positive feedback between adhesion formation and assembly of actomyosin bundles (stress fibers). The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient.

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Cell AdhesionCell MovementComputer SimulationCytoskeletonFocal AdhesionsIntegrinsMechanotransduction, CellularMembrane FluidityModels, BiologicalStress FibersComparative StudyEvaluation StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Igor L Novak, Boris M Slepchenko, Alex Mogilner, Leslie M Loew. 2004-12-23. Cooperativity between cell contractility and adhesion.. https://doi.org/10.1103/physrevlett.93.268109

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