Perfusion and diffusion MR imaging.

M D King; N van Bruggen; A L Busza; J Houseman; S R Williams; D G Gadian

doi:10.1002/mrm.1910240210

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Perfusion and diffusion MR imaging.

M D King·N van Bruggen·A L Busza·J Houseman·S R Williams·D G Gadian

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Abstract

Diffusion-weighted images of the rat brain were obtained using the pulsed-gradient spin-echo method. An attempt was made to extract perfusion-related parameters from signal intensity data taken from the caudate-putamen region of the images, by using a nonlinear least-squares calculation to fit the Le Bihan biexponential expression (Le Bihan et al., Radiology, 168, 497 (1988)) to the data. The perfusion-related parameters could not be obtained with sufficient accuracy to be useful, although the perfusion-weighted images appear to contain meaningful qualitative information. An analysis of the perfusion model is presented and shows why the Le Bihan pseudo-diffusion coefficient is particularly difficult to measure with reasonable accuracy.

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Animals Brain Female Image Processing, Computer-Assisted Least-Squares Analysis Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Rats Journal Article Research Support, Non-U.S. Gov't

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M D King, N van Bruggen, A L Busza, J Houseman, S R Williams, D G Gadian. 1992. Perfusion and diffusion MR imaging.. https://doi.org/10.1002/mrm.1910240210

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