Artificial diiron proteins: from structure to function.

Jennifer R Calhoun; Flavia Nastri; Ornella Maglio; Vincenzo Pavone; Angela Lombardi; William F DeGrado

doi:10.1002/bip.20230

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Artificial diiron proteins: from structure to function.

Jennifer R Calhoun·Flavia Nastri·Ornella Maglio·Vincenzo Pavone·Angela Lombardi·William F DeGrado

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Abstract

De novo protein design provides an attractive approach for the construction of models to probe the features required for the function of complex metalloproteins. These minimal models contain the essential elements believed necessary for activity of the protein. In this article, we summarize the design, structure determination, and functional properties of a family of artificial diiron proteins.

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Amino Acid Sequence Catalytic Domain Dimerization Iron Metalloproteins Models, Molecular Molecular Sequence Data Protein Conformation Protein Structure, Quaternary Static Electricity Thermodynamics Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Jennifer R Calhoun, Flavia Nastri, Ornella Maglio, Vincenzo Pavone, Angela Lombardi, William F DeGrado. 2005. Artificial diiron proteins: from structure to function.. https://doi.org/10.1002/bip.20230

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