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PubMed · 1570041

[Brief depressive affect].

H J Gertz
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Abstract

A 59-year-old patient suffered during three months from depressive episode. Thereafter he developed depressive attacks of 30 to 60 minutes duration, reoccurring weekly to every third week. The patient could be treated successfully with Carbamacepine.

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CarbamazepineDepressive DisorderDose-Response Relationship, DrugHumansMaleMiddle AgedPsychiatric Status Rating ScalesRecurrenceCase ReportsEnglish AbstractJournal Article

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H J Gertz. 1992. [Brief depressive affect].. https://pubmed.ncbi.nlm.nih.gov/1570041/

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PubMed1992

An immunodominant haptenic epitope of carbamazepine detected in serum from patients given long-term treatment with carbamazepine without allergic reaction.

An anticarbamazepine antibody was detected in the serum of a patient with severe carbamazepine-induced serum sickness. We found that the patient's T cells and IgG antibody recognized an epitope which appeared in subjects showing an allergic reaction, as well as that in subjects who showed no allergic reaction, after long-term carbamazepine therapy. These results show that an anti-carbamazepine immune response does not occur in the majority of subjects who undergo long-term carbamazepine therapy without developing allergic symptoms, although the immunodominant haptenic epitope of carbamazepine is present in their sera.

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