Swelling-based method for preparing stable, functionalized polymer colloids.

Anthony J Kim; Vinothan N Manoharan; John C Crocker

doi:10.1021/ja0450051

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Swelling-based method for preparing stable, functionalized polymer colloids.

Anthony J Kim·Vinothan N Manoharan·John C Crocker

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Abstract

We describe a swelling-based method to prepare sterically stabilized polymer colloids with different functional groups or biomolecules attached to their surface. It should be applicable to a variety of polymeric colloids, including magnetic particles, fluorescent particles, polystyrene particles, PMMA particles, and so forth. The resulting particles are more stable in the presence of monovalent and divalent salt than existing functionalized colloids, even in the absence of any surfactant or protein blocker. While we use a PEG polymer brush here, the method should enable the use of a variety of polymer chemistries and molecular weights.

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Colloids DNA, Single-Stranded Drug Stability Fluoresceins Hydrophobic and Hydrophilic Interactions Microspheres Osmolar Concentration Polyethylene Glycols Polystyrenes Surface-Active Agents Toluene Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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Anthony J Kim, Vinothan N Manoharan, John C Crocker. 2005-02-16. Swelling-based method for preparing stable, functionalized polymer colloids.. https://doi.org/10.1021/ja0450051

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