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PubMed · 15702602

Simultaneous confidence bounds for low-dose risk assessment with nonquantal data.

Walter W Piegorsch·R Webster West·Wei Pan·Ralph L Kodell
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Abstract

We study the use of simultaneous confidence bounds for making low-dose inferences in quantitative risk analysis. Confidence limits are constructed for outcomes measured on a continuous scale, assuming a simple linear model for the observed response. From the simultaneous confidence bounds, simultaneous lower limits on the benchmark dose associated with a particular risk are also constructed.

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AnimalsConfidence IntervalsDose-Response Relationship, DrugLinear ModelsMaleMonte Carlo MethodRatsRats, Inbred F344Risk AssessmentJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Walter W Piegorsch, R Webster West, Wei Pan, Ralph L Kodell. 2005. Simultaneous confidence bounds for low-dose risk assessment with nonquantal data.. https://doi.org/10.1081/bip-200040804

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