A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks.

Fernando Albericio; Klaus Burger; Javier Ruíz-Rodríguez; Jan Spengler

doi:10.1021/ol047653v

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PubMed · 15704903

A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks.

Fernando Albericio·Klaus Burger·Javier Ruíz-Rodríguez·Jan Spengler

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Abstract

The technique of choice for synthesis of small-scale depsipeptides is on a solid support. However, if expensive monomers have to be incorporated, solid-phase synthesis can quickly turn out to be unattractive because of its low atom economy. Herein, we describe a new type of recoverable and reuseable alpha-hydroxy acid building block for solid-phase synthesis and its application in the synthesis of a number of small cyclic depsipeptides. [structure: see text]

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Amino Acids Carboxylic Acids Depsipeptides Indicators and Reagents Models, Molecular Journal Article Research Support, Non-U.S. Gov't

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Fernando Albericio, Klaus Burger, Javier Ruíz-Rodríguez, Jan Spengler. 2005-02-17. A new strategy for solid-phase depsipeptide synthesis using recoverable building blocks.. https://doi.org/10.1021/ol047653v

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