Consistent re-modeling of signaling pathways and its implementation in the TRANSPATH database.

Claudia Choi; Torsten Crass; Alexander Kel; Olga Kel-Margoulis; Mathias Krull; Susanne Pistor; Anatolij Potapov; Nico Voss; Edgar Wingender

PubMed · 15706510

Consistent re-modeling of signaling pathways and its implementation in the TRANSPATH database.

Claudia Choi·Torsten Crass·Alexander Kel·Olga Kel-Margoulis·Mathias Krull·Susanne Pistor·Anatolij Potapov·Nico Voss·Edgar Wingender

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Abstract

The data model of the signaling pathways database TRANSPATH has been re-engineered to a three-layer model comprising experimental evidences and summarized pathway information, both in a mechanistically detailed manner, and a "semantic" projection for the abstract overview. Each molecule is described in the context of a certain reaction in the multidimensional space of posttranslational modification, molecular family relationships, and the biological species of its origin. The new model makes the data better suitable for reconstructing signaling pathways and networks and mapping expression data, for instance from microarray experiments, onto regulatory networks.

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Algorithms Artificial Intelligence Databases, Factual Gene Expression Regulation Information Storage and Retrieval Oligonucleotide Array Sequence Analysis Signal Transduction Software Journal Article Research Support, Non-U.S. Gov't

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Claudia Choi, Torsten Crass, Alexander Kel, Olga Kel-Margoulis, Mathias Krull, Susanne Pistor, Anatolij Potapov, Nico Voss, Edgar Wingender. 2004. Consistent re-modeling of signaling pathways and its implementation in the TRANSPATH database.. https://pubmed.ncbi.nlm.nih.gov/15706510/

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