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Multiple sclerosis: MHC associations and therapeutic implications.

Samantha Holmes·Manuel A Friese·Christian Siebold·E Yvonne Jones·John Bell·Lars Fugger
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Abstract

Multiple sclerosis (MS) is an autoimmune disease with an important genetic component. The strongest genetic association is with the major histocompatibility complex (MHC) region. Several MHC alleles predispose to the disease, the most prominent of which are certain alleles in the HLA-DR2 haplotype. Functional and structural studies have helped to explain the molecular basis of these associations. Although there is currently no curative treatment for MS, an increased understanding of the disease has aided the design of immunotherapies that act on the immune system more specifically than the longstanding drugs. Many of these therapies work at the antigen-specific level, disrupting the interaction between T-cell receptors and MHC molecules that leads to disease.

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AnimalsAutoantigensCD4-Positive T-LymphocytesDisease Models, AnimalGenetic Predisposition to DiseaseHLA-DR2 AntigenHaplotypesHumansImmunologic FactorsImmunosuppressive AgentsImmunotherapyLeukocyte Reduction ProceduresMajor Histocompatibility ComplexMiceMice, TransgenicMolecular MimicryMultiple SclerosisReceptors, Antigen, T-CellJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Samantha Holmes, Manuel A Friese, Christian Siebold, E Yvonne Jones, John Bell, Lars Fugger. 2005-02-14. Multiple sclerosis: MHC associations and therapeutic implications.. https://doi.org/10.1017/s1462399405008914

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