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Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation.

Ikuo Tsunoda·Li-Qing Kuang·Isaac Z M Igenge·Robert S Fujinami
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Abstract

We induced experimental allergic encephalomyelitis (EAE) in SJL/J mice, an animal model for multiple sclerosis (MS), using myelin oligodendrocyte glycoprotein (MOG)(92-106) peptide, following ultraviolet (UV) irradiation. While all control mice developed relapsing-remitting (RR)-EAE, UV irradiation induced secondary progressive (SP)-EAE in some of the mice. Although mild demyelination was observed with T cell infiltration in RR-EAE, large demyelinating lesions developed in SP-EAE with massive macrophage and neutrophil infiltration and immunoglobulin deposition, but with little T cell infiltration. UV irradiation induced higher anti-MOG antibody responses. In SP-EAE, lymphoproliferative responses and interferon-gamma production were decreased without alteration of interleukin-4.

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Amino Acid SequenceAnimalsCell MovementCentral Nervous SystemDose-Response Relationship, RadiationEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansImmunoglobulin GImmunoglobulinsLymphocyte ActivationMacrophagesMiceMolecular Sequence DataMultiple Sclerosis, Chronic ProgressiveMultiple Sclerosis, Relapsing-RemittingMyelin ProteinsMyelin SheathMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinSeverity of Illness IndexT-LymphocytesUltraviolet RaysComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Ikuo Tsunoda, Li-Qing Kuang, Isaac Z M Igenge, Robert S Fujinami. 2004-12-29. Converting relapsing remitting to secondary progressive experimental allergic encephalomyelitis (EAE) by ultraviolet B irradiation.. https://doi.org/10.1016/j.jneuroim.2004.11.007

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