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PubMed · 15711052

Neural stem cells: progenitors or panacea?

Corinna Klein·Gord Fishell
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Abstract

Are neural stem cells (NSCs) maintained as totipotent precursors by the specialized environment within the stem cell niche or are they simply progenitors, which, while retaining their ability to proliferate, are parcellated and restricted along with their postmitotic brethren? In this review, we focus on what has been learned in recent years about endogenous populations of NSCs in the embryonic and adult brain. We compare the data garnered from in vitro analysis to what has been learned from the transplantation of NSCs into the developing, adult or lesioned brain.

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AnimalsBrainBrain DiseasesCell DifferentiationCell LineageHumansNeuronsPluripotent Stem CellsSpinal Cord InjuriesStem Cell TransplantationStem CellsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Corinna Klein, Gord Fishell. Neural stem cells: progenitors or panacea?. https://doi.org/10.1159/000082129

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