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PubMed · 15713416

Glucokinase-activating ureas.

Arlindo L Castelhano·Hanqing Dong·Matthew C T Fyfe·Lisa S Gardner·Yukari Kamikozawa·Satomi Kurabayashi·Masao Nawano·Rikiya Ohashi·Martin J Procter·Li Qiu·Chrystelle M Rasamison·Karen L Schofield·Vilas K Shah·Kiichiro Ueta·Geoffrey M Williams·David Witter·Kosuke Yasuda
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Abstract

The synthesis, SAR and biological evaluation of a series of ureas that activate glucokinase, a target for diabetes therapy as a result of its critical role in the regulation of whole-body glucose homeostasis, are described. Some of the urea-containing glucokinase activators lowered blood glucose levels in vivo following oral dosing to C57BL/6J mice.

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Administration, OralAnimalsBlood GlucoseDiabetes MellitusEnzyme ActivationGlucokinaseHomeostasisHumansMiceMolecular StructureStructure-Activity RelationshipUreaJournal Article

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Arlindo L Castelhano, Hanqing Dong, Matthew C T Fyfe, Lisa S Gardner, Yukari Kamikozawa, Satomi Kurabayashi, Masao Nawano, Rikiya Ohashi, Martin J Procter, Li Qiu, Chrystelle M Rasamison, Karen L Schofield, Vilas K Shah, Kiichiro Ueta, Geoffrey M Williams, David Witter, Kosuke Yasuda. 2005-03-01. Glucokinase-activating ureas.. https://doi.org/10.1016/j.bmcl.2004.12.083

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