Cisplatin nanocapsules.

Anton I P M de Kroon; Rutger W H M Staffhorst; Ben de Kruijff; Koert N J Burger

doi:10.1016/s0076-6879(05)91006-9

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PubMed · 15721377

Cisplatin nanocapsules.

Anton I P M de Kroon·Rutger W H M Staffhorst·Ben de Kruijff·Koert N J Burger

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Abstract

Cisplatin nanocapsules represent a novel lipid formulation of the anticancer drug cis-diamminedichloroplatinum(II), in which nanoprecipitates of cisplatin are covered by a phospholipid bilayer coat consisting of an equimolar mixture of phosphatidylcholine and phosphatidylserine. Cisplatin nanocapsules are characterized by an unprecedented cisplatin-to-lipid molar ratio and exhibit strongly improved cytotoxicity against tumor cells in vitro compared with the free drug. Here, methods for preparing and characterizing cisplatin nanocapsules are reported.

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Animals Antineoplastic Agents Cisplatin Drug Carriers Drug Compounding Humans Molecular Structure Nanostructures Phospholipids Journal Article Research Support, Non-U.S. Gov't

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Anton I P M de Kroon, Rutger W H M Staffhorst, Ben de Kruijff, Koert N J Burger. 2005. Cisplatin nanocapsules.. https://doi.org/10.1016/s0076-6879(05)91006-9

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