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PubMed · 15721388

Liposomal polyene antibiotics.

Agatha W K Ng·Kishor M Wasan·Gabriel Lopez-Berestein
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Abstract

Polyene antibiotics (i.e., amphotericin B and nystatin) have been incorporated into lipid-based delivery systems to decrease their toxicity and enhance their therapeutic index, the most common being liposomes. This chapter describes the protocols for preparing liposomal amphotericin B and determining the efficacy and toxicity of the formulations in animals. Furthermore, methods for determining the pharmacokinetics and drug distribution after administration of amphotericin B in lipid-based delivery systems are discussed. Procedures for comparing the toxicity of different amphotericin B formulations in cell culture studies are also elucidated.

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Amphotericin BAnimalsAnti-Bacterial AgentsCandidiasisCell LineDrug CarriersLiposomesMiceNystatinRabbitsJournal Article

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BibTeXRIS

Agatha W K Ng, Kishor M Wasan, Gabriel Lopez-Berestein. 2005. Liposomal polyene antibiotics.. https://doi.org/10.1016/s0076-6879(05)91017-3

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Amphotericin B↗
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Amphotericin B↗