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How do cofactors modulate protein folding?

Catherine L Higgins·B K Muralidhara·Pernilla Wittung-Stafshede
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Abstract

Cofactors are essential components of many proteins for biological activity. Characterization of several cofactor-binding proteins has shown that cofactors often have the ability to interact specifically with the unfolded polypeptides. This suggests that cofactor-coordination prior to polypeptide folding may be a relevant path in vivo. By binding before folding, the cofactor may affect both the mechanism and speed of folding. Here, we discuss three different cofactors that modulate protein-folding processes in vitro.

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AnimalsAzurinCoenzymesFerredoxinsFlavodoxinHumansMetalsModels, MolecularProtein FoldingProtein Structure, QuaternaryJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Catherine L Higgins, B K Muralidhara, Pernilla Wittung-Stafshede. 2005. How do cofactors modulate protein folding?. https://doi.org/10.2174/0929866053005782

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