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New developments in iron chelators.

Melody J Cunningham·David G Nathan
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Abstract

PURPOSE OF REVIEW: For three decades, deferoxamine has been the only approved iron chelator. This drug has an extremely short-half life and is not orally absorbed; thus, a search has been ongoing for alternative chelators with less onerous delivery. Recently, several oral iron chelators and variations of deferoxamine to prolong the half-life have been developed. These and the methods of monitoring iron overload are the subjects of this review. RECENT FINDINGS: New chelators, combinations of chelators and regimens for known chelators and their safety and efficacy are being studied in important preclinical and clinical trials. SUMMARY: The care and clinical outcomes of patients with thalassemia and other iron-overload disorders may be markedly improved by recent discoveries and novel approaches to chelation therapy.

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Heart DiseasesHumansIron Chelating AgentsIron OverloadThalassemiaJournal ArticleReview

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Melody J Cunningham, David G Nathan. 2005. New developments in iron chelators.. https://doi.org/10.1097/01.moh.0000152631.63469.07

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