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PubMed · 15727206

[Structure, function and modulation of actin-related protein 2/3 complex].

Xio-Wei Gong·Yong Jiang
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Abstract

Microfilaments, composed of global actins, involve in many important physiological activities, such as the maintenance of cell shape and cell migration. Actin-related protein 2/3 ( Arp2/3) complex plays a key role in microfilament formation. Actin-related protein 2/3 ( Arp2/3 ) complex which is composed of seven different subunits is subjected to the modulation of many nucleation promoting factors (NPFs) and cooperates with these factors to regulate the actin nucleation. The study of the structure, function and modulation of Arp2/3 complex is important in understanding the mechanism of the formation of microfilament and the interaction between cytoskeleton and signaling molecules.

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Actin CytoskeletonActin-Related Protein 2Actin-Related Protein 3AnimalsCytoskeletal ProteinsHumansMaturation-Promoting FactorMicrofilament ProteinsSignal TransductionEnglish AbstractJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Xio-Wei Gong, Yong Jiang. 2004. [Structure, function and modulation of actin-related protein 2/3 complex].. https://pubmed.ncbi.nlm.nih.gov/15727206/

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