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Lambda interferon inhibits hepatitis B and C virus replication.

Michael D Robek·Bryan S Boyd·Francis V Chisari
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Abstract

Lambda interferon (IFN-lambda) induces an intracellular IFN-alpha/beta-like antiviral response through a receptor complex distinct from the IFN-alpha/beta receptor. We therefore determined the ability of IFN-lambda to inhibit hepatitis B virus (HBV) and hepatitis C virus (HCV) replication. IFN-lambda inhibits HBV replication in a differentiated murine hepatocyte cell line with kinetics and efficiency similar to IFN-alpha/beta and does not require the expression of IFN-alpha/beta or IFN-gamma. Furthermore, IFN-lambda blocked the replication of a subgenomic and a full-length genomic HCV replicon in human hepatocyte Huh7 cells. These results suggest the possibility that IFN-lambda may be therapeutically useful in the treatment of chronic HBV or HCV infection.

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AnimalsAntiviral AgentsCells, CulturedHepacivirusHepatitis B virusHumansInterferonsMiceVirus ReplicationJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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Michael D Robek, Bryan S Boyd, Francis V Chisari. 2005. Lambda interferon inhibits hepatitis B and C virus replication.. https://doi.org/10.1128/jvi.79.6.3851-3854.2005

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