The lambda5-VpreB1 locus--a model system for studying gene regulation during early B cell development.

Pierangela Sabbattini; Niall Dillon

doi:10.1016/j.smim.2005.01.004

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The lambda5-VpreB1 locus--a model system for studying gene regulation during early B cell development.

Pierangela Sabbattini·Niall Dillon

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Abstract

The lambda5 and VpreB genes encode the components of the surrogate light-chain, which forms part of the pre-B cell receptor. In mouse, the lambda5 and VpreB1 genes of mouse are closely linked and coordinately regulated by a locus control region (LCR). Activation of the genes in pro-B cells depends on the combined effects of early B cell factor (EBF) and the E2A factors E12 and E47. Silencing of lambda5 expression in mature B cells occurs through the action of Ikaros on the gene promoter where it may compete for binding of EBF and initiate the formation of a silent chromatin structure.

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Animals B-Lymphocytes Chromatin Assembly and Disassembly Gene Expression Regulation, Developmental Gene Silencing Immunoglobulin Light Chains Immunoglobulin Light Chains, Surrogate Membrane Glycoproteins Mice Transcription Factors Journal Article Research Support, Non-U.S. Gov't Review

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Pierangela Sabbattini, Niall Dillon. 2005. The lambda5-VpreB1 locus--a model system for studying gene regulation during early B cell development.. https://doi.org/10.1016/j.smim.2005.01.004

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