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Improving opioid effectiveness: from ideas to evidence.

Eija Kalso
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Abstract

Opioid effectiveness can be improved by individualizing dosing, route of administration and the drug. Particularly in the treatment of chronic non-cancer pain, careful patient selection is essential. The current review concentrates on new ideas about improving opioid effectiveness by increasing efficacy or reducing adverse effects by combining other drugs that modulate opioid receptor mediated effects. These pharmacological "oipioid adjuvants" include e.g. alpha(2)-adrenergic agonists, non-steroidal anti-flammatory analgesics, NMDA-receptor antagonists, CCK-antagonists, gabapentinoids and NK-1 receptor antagonists. The theoretical background and the clinical evidence of these combinations will be discussed.

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Adrenergic alpha-AgonistsAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalChronic DiseaseDrug Therapy, CombinationExcitatory Amino Acid AntagonistsHumansNarcotic AntagonistsPainReceptors, CholecystokininTreatment OutcomeJournal ArticleReview

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Eija Kalso. 2005. Improving opioid effectiveness: from ideas to evidence.. https://doi.org/10.1016/j.ejpain.2004.05.007

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