Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes.

Katarzyna Kozar; Piotr Sicinski

doi:10.4161/cc.4.3.1551

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Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes.

Katarzyna Kozar·Piotr Sicinski

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Abstract

D-type cyclins (cyclin D1, D2 and D3) and their associated cyclin-dependent kinases CDK4 and CDK6 were thought to represent important, perhaps essential components of the core cell cycle apparatus. However, recent analyses of mice lacking D-cyclins, or CDK4 and CDK6 reveal that these proteins are critically required for proliferation only in the selected cell types. Intriguingly, several compartments can develop in the absence of cyclin D-CDK4/6 activity, revealing that these cells can proliferate in a cyclin D-independent fashion.

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Animals Cell Cycle Cell Proliferation Cyclin D Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase 6 Cyclins Gene Expression Regulation, Developmental Mice Mice, Transgenic Models, Biological Phenotype Saccharomyces cerevisiae Time Factors Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S.Review

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Katarzyna Kozar, Piotr Sicinski. 2005-03-18. Cell cycle progression without cyclin D-CDK4 and cyclin D-CDK6 complexes.. https://doi.org/10.4161/cc.4.3.1551

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