Spindle assembly: asters part their separate ways.

Jody Rosenblatt

doi:10.1038/ncb0305-219

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Spindle assembly: asters part their separate ways.

Jody Rosenblatt

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Abstract

Cells have developed diverse ways to separate two microtubule asters to form a mitotic spindle. Here, I focus on two mechanisms used to position asters around chromosomes during mitosis: first, aster migration around the nuclear envelope and, second, aster attachment to a contractile cortex at the plasma membrane after the nuclear envelope has broken down. Although certain cell types use one mechanism predominantly, most rely on both to ensure proper spindle assembly.

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Animals Caenorhabditis elegans Cell Movement Cell Nucleus Centrosome Chromosomes Cytoplasm Drosophila Kinesins Mitosis Models, Biological Spindle Apparatus Journal Article Research Support, Non-U.S. Gov't

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Jody Rosenblatt. 2005. Spindle assembly: asters part their separate ways.. https://doi.org/10.1038/ncb0305-219

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