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PubMed · 15741316

Perspective: machines for RNAi.

Yukihide Tomari·Phillip D Zamore
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Abstract

RNA silencing pathways convert the sequence information in long RNA, typically double-stranded RNA, into approximately 21-nt RNA signaling molecules such as small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs and miRNAs provide specificity to protein effector complexes that repress mRNA transcription or translation, or catalyze mRNA destruction. Here, we review our current understanding of how small RNAs are produced, how they are loaded into protein complexes, and how they repress gene expression.

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AnimalsDown-RegulationHumansProtein BiosynthesisRNA StabilityRNA, MessengerRNA, Small InterferingRNA-Binding ProteinsSignal TransductionTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Yukihide Tomari, Phillip D Zamore. 2005-03-01. Perspective: machines for RNAi.. https://doi.org/10.1101/gad.1284105

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