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PubMed · 15744689

Latest development in split liver transplantation.

Nils R Frühauf·Massimo Malagó·Andrea Frilling·Susanne Beckebaum·Christoph E Broelsch
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Abstract

Currently, orthotopic liver transplantation (LT) represents the treatment of choice for most end-stage liver diseases. Advances in surgical techniques and immunosuppressive therapy have markedly increased its success. However, the main obstacle in LT remains the lack of donor organs with a current mortality rate for patients on the waiting list of up to 20%. This chapter focuses on developments in SLT techniques and living-donor LT to alleviate this problem. SLT yields a net gain of organs, in that it uses one organ to save either an adult and a child, or two adults. The initially used technique of ex-situ splitting is being replaced progressively by the in-situ splitting technique, which yields better preserved grafts. The latest step has been the introduction of living-donor segmental LT. The systematic combination of both techniques may lead to a further reduction of mortality for patients on the waiting list for LT.

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FemaleForecastingGraft RejectionGraft SurvivalHumansLiverLiver FailureLiver Function TestsLiver TransplantationMalePerioperative CarePrognosisRisk AssessmentSeverity of Illness IndexSurvival AnalysisTissue DonorsTissue and Organ ProcurementWaiting ListsComparative StudyJournal ArticleReview

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Nils R Frühauf, Massimo Malagó, Andrea Frilling, Susanne Beckebaum, Christoph E Broelsch. 2004. Latest development in split liver transplantation.. https://pubmed.ncbi.nlm.nih.gov/15744689/

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