Structural clues to Rab GTPase functional diversity.

Suzanne R Pfeffer

doi:10.1074/jbc.r500003200

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Structural clues to Rab GTPase functional diversity.

Suzanne R Pfeffer

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Abstract

Rab GTPases are key regulators of membrane trafficking in eukaryotes. Recent structural analysis of a number of Rabs, either alone or in complex with partner proteins, has provided new insight into the importance of both conserved and non-conserved features of these proteins that specify their unique functions and localizations. This review will highlight what we have learned from crystallographic analysis of this important protein family.

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Amino Acid Motifs Amino Acid Sequence Conserved Sequence Evolution, Molecular Humans Molecular Sequence Data Molecular Structure Protein Structure, Tertiary Structure-Activity Relationship Yeasts rab GTP-Binding Proteins Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Suzanne R Pfeffer. 2005-03-03. Structural clues to Rab GTPase functional diversity.. https://doi.org/10.1074/jbc.r500003200

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