First-trimester screening: an overview.

Bernd Eiben; Ralf Glaubitz

doi:10.1369/jhc.4b6420.2005

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PubMed · 15750002

First-trimester screening: an overview.

Bernd Eiben·Ralf Glaubitz

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Abstract

An improvement in prenatal screening for chromosomal defects has been achieved by combining sonography and biochemical markers. Analyzing markers taken from maternal blood such as pregnancy-associated plasma protein A and free beta-human chorionic gonadotropin in combination with the ultrasound marker nuchal translucency provides detection rates of 90% for the most important chromosomal anomalies. In addition, nuchal translucency is a marker for severe heart defects. This report discusses the potential of new markers such as the nasal bone.

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Age Factors Biomarkers Chorionic Gonadotropin, beta Subunit, Human Chromosome Aberrations Down Syndrome Female Humans Nasal Bone Nuchal Translucency Measurement Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A Prenatal Diagnosis Ultrasonography, Prenatal Journal Article Review

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Bernd Eiben, Ralf Glaubitz. 2005. First-trimester screening: an overview.. https://doi.org/10.1369/jhc.4b6420.2005

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