Exiting the endoplasmic reticulum.

Joseph D Mancias; Jonathan Goldberg

doi:10.1111/j.1600-0854.2005.00279.x

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Exiting the endoplasmic reticulum.

Joseph D Mancias·Jonathan Goldberg

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Abstract

Vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex constitutes the initial step in protein secretion. COPII-coated vesicles mediate the export of newly synthesized proteins from the ER, and this transport step is coupled with COPI-mediated retrograde traffic to form a transport circuit that supports the compositional asymmetry of the ER-Golgi system. Biochemical and structural studies have advanced our understanding of the mechanisms that control vesicle formation and cargo-protein capture. Recent work has highlighted the function of transitional ER regions in specifying the location of COPII budding.

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Animals COP-Coated Vesicles Cell Membrane Endoplasmic Reticulum Protein Transport Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Joseph D Mancias, Jonathan Goldberg. 2005. Exiting the endoplasmic reticulum.. https://doi.org/10.1111/j.1600-0854.2005.00279.x

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