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Clostridium difficile causing acute renal failure: case presentation and review.

Jasmin Arrich·Gottfried-H Sodeck·Gurkan Sengolge·Christoforos Konnaris·Marcus Mullner·Anton-N Laggner·Hans Domanovits
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Abstract

AIM: Clostridium difficile infection is primarily a nosocomial infection but asymptomatic carriers of Clostridium difficile can be found in up to 5% of the general population. Ampicillin, cephalosporins and clindamycin are the antibiotics that are most frequently associated with Clostridium difficile-associated diarrhea or colitis. Little is known about acute renal failure as a consequence of Clostridium difficile-associated diarrhea. METHODS: In this case report, we describe the course of Clostridium difficile-associated diarrhea in an 82-year-old patient developing acute renal failure. Stopping the offending agent and symptomatic therapy brought a rapid improvement of diarrhea and acute renal failure, full recovery was gained 18 d after admission. In a systematic review we looked for links between the two conditions. RESULTS: The link between Clostridium difficile-associated diarrhea and acute renal failure in our patient was most likely volume depletion. However, in experimental studies a direct influence of Clostridium difficile toxins on renal duct cells could be shown. CONCLUSION: Rapid diagnosis, nonspecific supportive treatment and specific antibiotic treatment, especially in the elderly, may lower excess mortality Clostridium difficile-associated diarrhea and renal failure being possible complications.

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Acute Kidney InjuryAgedAged, 80 and overAnti-Infective AgentsClostridioides difficileEnterocolitis, PseudomembranousHumansMaleMetronidazoleJournal ArticleSystematic Review

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Jasmin Arrich, Gottfried-H Sodeck, Gurkan Sengolge, Christoforos Konnaris, Marcus Mullner, Anton-N Laggner, Hans Domanovits. 2005-02-28. Clostridium difficile causing acute renal failure: case presentation and review.. https://doi.org/10.3748/wjg.v11.i8.1245

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