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Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels.

Marion Maire·Frederic Chaubet·Pierrer Mary·Cinderella Blanchat·Alain Meunier·Delphine Logeart-Avramoglou
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Abstract

This study evaluated functionalized dextran-derived hydrogels as BMP carriers using both in vitro and in vivo models. In vitro release kinetics indicated that dextran-derived hydrogels could retain rhBMP-2 growth factor in a variable manner depending on their functionalization ratio. The potential of these hydrogels when combined with extracted bovine BMP to enhance the bone formation was evaluated in a rat ectopic model. The largest osteoinduction was found when using hydrogels exhibiting the highest growth factor retention capacity. In addition, some implanted hydrogels demonstrated a capacity to induce an in-vivo calcification certainly related to their chemical composition. These properties make these materials interesting osteoconductive BMP carriers, allowing to decrease the amount of implanted factor required for bone regeneration.

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AnimalsBone Morphogenetic Protein 2Bone Morphogenetic ProteinsBone and BonesCattleCoated Materials, BiocompatibleDelayed-Action PreparationsDextransDiffusionDose-Response Relationship, DrugDrug ImplantsHumansHydrogelsMaleMaterials TestingOsteogenesisRatsRats, Sprague-DawleyTransforming Growth Factor betaComparative StudyEvaluation StudyJournal ArticleResearch Support, Non-U.S. Gov't

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Marion Maire, Frederic Chaubet, Pierrer Mary, Cinderella Blanchat, Alain Meunier, Delphine Logeart-Avramoglou. 2005. Bovine BMP osteoinductive potential enhanced by functionalized dextran-derived hydrogels.. https://doi.org/10.1016/j.biomaterials.2005.01.020

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