[Estrogen and bone metabolism--basic research].

Hirotaka Kawano; Hiroshi Kawaguchi

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PubMed · 15775420

[Estrogen and bone metabolism--basic research].

Hirotaka Kawano·Hiroshi Kawaguchi

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Abstract

Biological functions of estrogen are exerted mainly through binding to the nuclear receptors, estrogen receptor alpha, beta (ERalpha, beta) , which regulate the transcription of target genes. Recent studies have revealed its direct effect on bone at molecular level, which is mediated by a complicated network of various cytokines. In addition, it is suggested not only that both estrogen and androgen have independent roles in bone metabolism, but also they have common non-genotropic and anti-apoptotic pathways in bone cells.

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Hirotaka Kawano, Hiroshi Kawaguchi. 2002. [Estrogen and bone metabolism--basic research].. https://pubmed.ncbi.nlm.nih.gov/15775420/

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